The desert planet known as Dune has been destroyed by the dreaded and mysterious Honored Maters, a group of sexually skilled women from beyond the borders of the Known Universe. These women who use sex to enslave men are now bent on destroying the Bene Gesserit Sisterhood. The Bene Gesserit lost their Surperem Bashar Miles Teg in the attack. Yet, the Bene Gesserit's plots have not died with the man nor with the planet. Now the new Reverend Mother Superior Darwi Odrade must fulfill the hopes of the wounded Sisterhood. As the systematic genocide of the Sisters spreads throughout the Universe, Odrade must use the few, but fantastic, tools she had collected: the last Tleilaxu Master Scytale, the reawakened ghola Mentat Duncan Idaho, their captive Honored Mater Murbella, the last sandworm in the Known Universe, and a no-ship to hold and hide them. The young girl Sheeana with the ability to command the sandworms was rescued from doomed Rakis with Odrade and is now a Reverend Mother and has learned the sexual skills of the Honored Maters. Duncan Idaho tries to hide his Mentat abilities and his multiple past lives for fear of the Bene Gesserit wrath. The Bene Gesserit fear another Kwisarts Haderade almost as much as they fear extinction. Idaho fears the Bene Gesserit, especially that his nemesis Bellonda, Odrade's Mentat, will see him as another Kwisats Haderah. The Tleilaxu had given Idaho the sexual knowledge of the Honored Maters and having used his skill, Idaho and Murbella bound each other to one another, producing many children for the Bene Gesserit. Murbella is near the completion of her Bene Gesserit training to become a Reverend Mother herself. Idaho continues to train men to repel and enslave Honored Maters and has fallen in love with Murbella. As her time to become a Reverend Mother approaches, he fears losing her more and more. With the last sandworm, Sheeana begins to turn Chapterhouse, the Bene Gesserit homeworld, into a new Dune. Now both factions, Bene Gesserit and Honored Mater, must battle for existence as the Bene Gesserit learn their hunters are being hunted themselves. Before the destruction of the planet Lampadas, Reverend Mother Lucia shared with Reverend Mothers and acolytes and now hold the hoard of Lampadas in her Other Memory, now she must find a way to get her Other Memory back to Capterhouse. Darwi Odrade also oversees the development of the first Bene Gesserit axolotl tank and the first Bene Gesserit ghola, her father, Miles Teg.